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RNA-seq Reveals Dysregulation of Novel Melanocyte Genes upon Oxidative Stress: Implications in Vitiligo Pathogenesis

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In AP models, excessive activation of DRP1 and/or downregulation of MFN1/2 and OPA1 has been associated with pathological mitochondrial fragmentation, loss of m, decreased ATP production, and accumulation of dysfunctional mitochondria (35, 38)